Osgood-Schlatter disease is probably the most frequent cause of knee pain in children. Both boys and girls are equally vulnerable to its debilitating effects. Osgood-Schlatter disease is always characterized by activity-related pain that occurs a few inches below the knee-cap, or patella, on the front of the knee. If unresolved it can be painful, of long duration, and have permanent detrimental effects both on the bone, as well as on a young athlete’s performance.